Small Volume Biopsy in Pediatric Tumors by Jerzy Klijanienko Živa Pohar Marinšek & Henryk A Domanski

Author:Jerzy Klijanienko, Živa Pohar Marinšek & Henryk A Domanski
Language: eng
Format: epub
Publisher: Springer International Publishing, Cham

4.1.4 Differential Diagnosis

Poorly differentiated and differentiated neuroblastomas , ganglioneuroblastomas, and ganglioneuromas exhibit characteristic morphologic patterns allowing the proper diagnosis [9, 12–14]. Undifferentiated neuroblastoma should be differentiated from monophasic blastematous nephroblastoma, Ewing’s sarcoma/pPNET, and rhabdomyosarcoma, especially in unusual anatomic localizations [15, 16]. The presence of epithelial structures in nephroblastoma is a main parameter allowing a correct diagnosis. Ewing sarcoma is usually composed of a double population of round cells with occasional rosette-formation, but neuropil is always absent. Rhabdomyosarcoma (especially alveolar type) is composed of dispersed round cell with characteristic rhabdomyoblastic morphology. Rosettes and neuropil are always absent.

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